Editorial policies

SpringerOpen, as part of SpringerNature, is a member of the Committee on Publication Ethics (COPE) and endorses the World Association of Medical Editors (WAME) Policy Statement on Geopolitical Intrusion on Editorial Decisions. SpringerOpen also endorses the International Committee of Medical Journal Editors (ICMJE) Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals. Submission of a manuscript to a SpringerOpen journal implies that all authors have read and agreed to its content and that the manuscript conforms to the journal’s policies. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Communicate with Respect

At Springer Nature we believe that only through relationships based upon mutual respect can we build trust and deliver quality publishing products and services to the communities we serve. Our staff are expected to behave professionally and respectfully at all times when engaging with authors, reviewers and readers. Likewise, we expect the same standards of behavior from the academic community and the public in their interactions with our staff. We do not tolerate aggressive behavior, or any form of harassment, bullying or discrimination directed against Springer Nature staff. We reserve the right to bring serious cases to the attention of employers or local authorities, if needed, and may refuse to interact, or do business, with individuals who repeatedly or seriously violate this policy.

Ethics and consent

Ethics approval

Research involving human participants, human material, or human data, must have been performed in accordance with the Declaration of Helsinki and must have been approved by an appropriate ethics committee. A statement detailing this, including the name of the ethics committee and the reference number where appropriate, must appear in all manuscripts reporting such research. If a study has been granted an exemption from requiring ethics approval, this should also be detailed in the manuscript (including the name of the ethics committee that granted the exemption). Further information and documentation to support this should be made available to the Editor on request. Manuscripts may be rejected if the Editor considers that the research has not been carried out within an appropriate ethical framework. In rare cases, the Editor may contact the ethics committee for further information.

Retrospective ethics approval

If a study has not been granted ethics committee approval prior to commencing, retrospective ethics approval usually cannot be obtained and it may not be possible to consider the manuscript for peer review. The decision on whether to proceed to peer review in such cases is at the Editor's discretion.

New clinical tools and procedures

Authors reporting the use of a new procedure or tool in a clinical setting, for example as a technical advance or case report, must give a clear justification in the manuscript for why the new procedure or tool was deemed more appropriate than usual clinical practice to meet the patient’s clinical need. Such justification is not required if the new procedure is already approved for clinical use at the authors’ institution. Authors will be expected to have obtained ethics committee approval and informed patient consent for any experimental use of a novel procedure or tool where a clear clinical advantage based on clinical need was not apparent before treatment.

Consent to participate

For all research involving human participants, informed consent to participate in the study should be obtained from participants (or their parent or legal guardian in the case of children under 16) and a statement to this effect should appear in the manuscript. For manuscripts reporting studies involving vulnerable groups (for example, unconscious patients) where there is the potential for coercion (for example prisoners) or where consent may not have been fully informed, manuscripts will be considered at the editor’s discretion and may be referred to an internal editorial oversight group for further scrutiny. Consent must be obtained for all forms of personally identifiable data including biomedical, clinical, and biometric data. In the case of articles describing human transplantation studies, authors must include a statement declaring that no organs/tissues were obtained from prisoners and must also name the institution(s)/clinic(s)/department(s) via which organs/tissues were obtained. Documentary evidence of consent must be supplied if requested.

Access to publications

All SpringerOpen publications are open access

Every article appearing in any SpringerOpen journal and any book published with SpringerOpen is 'open access', meaning that:

  1. The article/book is universally and freely accessible via the Internet, in an easily readable format. All publications are deposited immediately upon publication, without embargo, in an agreed format - current preference is XML with a declared DTD - in at least one widely and internationally recognized open access repository.
  2. The author(s) or copyright owner(s) irrevocably grant(s) to any third party, in advance and in perpetuity, the right to use, reproduce or disseminate the article/book in its entirety or in part, in any format or medium, provided that no substantive errors are introduced in the process, proper attribution of authorship and correct citation details are given, and that the bibliographic details are not changed. If the article/book is reproduced or disseminated in part, this must be clearly and unequivocally indicated.

Springer is committed permanently to maintaining this open access publishing policy, retrospectively and prospectively, in all eventualities, including any future changes in ownership.

Research involving human embryos, gametes, and stem cells

Manuscripts that report experiments involving the use of human embryos and gametes, human embryonic stem cells and related materials, and clinical applications of stem cells must include confirmation that all experiments were performed in accordance with relevant guidelines and regulations (See also Ethics and Consent)

The manuscript should include an ethics statement identifying the institutional and/or national research ethics committee (including the name of the ethics committee) approving the experiments and describing any relevant details. Authors should confirm that informed consent (See also Ethics and Consent and Consent for publication) was obtained from all recipients and/or donors of cells or tissues, where necessary, and describe the conditions of donation of materials for research, such as human embryos or gametes. Copies of approval and redacted consent documents may be requested by the Editor.

We encourage authors to follow the principles laid out in the ISSCR Guidelines for Stem Cell Research and Clinical Translation.

In deciding whether to publish papers describing modifications of the human germline, the Editors are guided by safety considerations, compliance with applicable regulations, as well as the status of the societal debate on the implications of such modifications for future generations. In case of concerns regarding a particular type of study the Editor may seek advice from the Springer Nature Research Integrity Group.

The decision to publish a paper is the responsibility of the Editor-in-Chief of the Journal.

Sex and gender in research (SAGER)

We encourage our authors to follow the ‘Sex and Gender Equity in Research – SAGER – guidelines’ and to include sex and gender considerations where relevant. Authors should use the terms sex (biological attribute) and gender (shaped by social and cultural circumstances) carefully in order to avoid confusing both terms. Article titles and/or abstracts should indicate clearly what sex(es) the study applies to. Authors should also describe in the background, whether sex and/or gender differences may be expected; report how sex and/or gender were accounted for in the design of the study; provide disaggregated data by sex and/or gender, where appropriate; and discuss respective results. If a sex and/or gender analysis was not conducted, the rationale should be given in the Discussion. We suggest that our authors consult the full guidelines before submission.

Research involving animals

Experimental research on vertebrates or any regulated invertebrates must comply with institutional, national, or international guidelines, and where available should have been approved by an appropriate ethics committee. The Basel Declaration outlines fundamental principles to adhere to when conducting research in animals and the International Council for Laboratory Animal Science (ICLAS) has also published ethical guidelines.

A statement detailing compliance with relevant guidelines (e.g. the revised Animals (Scientific Procedures) Act 1986 in the UK and Directive 2010/63/EU in Europe) and/or ethical approval (including the name of the ethics committee and the reference number where appropriate) must be included in the manuscript. If a study has been granted an exemption from requiring ethics approval, this should also be detailed in the manuscript (including the name of the ethics committee that granted the exemption and the reasons for the exemption). The Editor will take account of animal welfare issues and reserves the right to reject a manuscript, especially if the research involves protocols that are inconsistent with commonly accepted norms of animal research. In rare cases, the Editor may contact the ethics committee for further information.

For experimental studies involving client-owned animals, authors must also document informed consent from the client or owner and adherence to a high standard (best practice) of veterinary care.

Field studies and other non-experimental research on animals must comply with institutional, national, or international guidelines, and where available should have been approved by an appropriate ethics committee. A statement detailing compliance with relevant guidelines and/or appropriate permissions or licences must be included in the manuscript. We recommend that authors comply with the IUCN Policy Statement on Research Involving Species at Risk of Extinction and the Convention on the Trade in Endangered Species of Wild Fauna and Flora.

Research involving plants

Experimental research and field studies on plants (either cultivated or wild), including the collection of plant material, must comply with relevant institutional, national, and international guidelines and legislation.

Manuscripts should include a statement specifying the appropriate permissions and/or licences for collection of plant or seed specimens. We recommend that authors comply with the IUCN Policy Statement on Research Involving Species at Risk of Extinction and the Convention on the Trade in Endangered Species of Wild Fauna and Flora.

To support reproducibility, voucher specimens for all wild plants described in a manuscript must be deposited in a public herbarium or other public collection that provides access to deposited material. Information on the voucher specimen and who identified it must be included in the manuscript.

Research involving palaeontological and geological material

Details of palaeontological specimens and geological samples should include clear provenance information to ensure full transparency of the research.

It is recognized that precise provenance information may not be available for older museum collections. In circumstances where providing specific provenance information may compromise the security of palaeontological or geological sites it may be appropriate to exclude detailed locality information.

Samples must always be collected and exported in a responsible manner and in accordance with applicable local and national laws. Any submission detailing new material should include information regarding the requisite permissions obtained and the issuing authority. Authors may be required to provide specific supporting documentation upon request.

Type, figured and cited palaeontological specimens, should be deposited in a recognised museum or collection to permit free access by other researchers in perpetuity. Sufficient information on the repository, including the assigned unique catalogue numbers (where applicable), should be provided to allow the specimens to be traced.

We encourage deposition of 3-D scans of fossil specimens (where appropriate) within a permanent, accessible repository to facilitate study by the scientific community.

Dual Use Research of Concern

Some manuscripts provide information that could be directly misapplied to pose a significant threat to public health, safety or security, agricultural crops and other plants, animals, or the environment. For such information to be published, the benefit to the research community, society, or to public health, must outweigh any risks. We reserve the right to take expert advice in cases where we believe that concerns may arise, and we may require a manuscript to undergo peer review specifically to assess the dual use risk. Where the risk of misuse outweighs any potential benefit, publication is declined; published content may be corrected, retracted or removed.

Researchers are expected to comply with their institutional and funder’s requirements, as well as any national regulations. They should be aware of dual-use concerns related to their work and take steps to minimize misuse of their research. Such concerns include, but are not limited to, biosecurity, nuclear and chemical threats. Where relevant regulations exist, authors should disclose whether their study is subject to consideration as dual use research of concern; if it is, the manuscript should report the authority granting approval and reference number for the regulatory approval. When the study reports material that can be harmful outside the laboratory context, the manuscript should describe appropriate containment (e.g. biosafety) procedures.

We recognize the widespread view that openness in science helps to alert society to potential threats and to defend against them, and we anticipate that only very rarely will the risks be perceived as outweighing the benefits of publishing a paper that has otherwise been deemed appropriate for publication.

Standards for research in complementary and alternative medicine

Springer Nature journals are committed to evidence-based research. We believe that Complementary and Alternative Medicine (CAM) research should be held to the same standards and evidence threshold as those of medicine research.

We welcome manuscripts for submission which meet the following clinical research standards:

Consent for publication

For all manuscripts that include details, images, or videos relating to an individual person, written informed consent for the publication of these details must be obtained from that person (or their parent or legal guardian in the case of children under 18). The consent must be for publication of their details under the relevant Creative Commons license (such that they will be freely available on the internet). If the person has died, consent for publication must be obtained from their next of kin. The manuscript must include a statement that written informed consent for publication was obtained.

Authors can use the consent form to obtain consent for publication, or a consent form from their own institution or region if appropriate. The consent form must state that the details/images/videos will be freely available on the internet and may be seen by the general public. The consent form must be made available to the Editor if requested, and will be treated confidentially.

In cases where images are entirely unidentifiable and there are no details on individuals reported within the manuscript, consent for publication of images may not be required. The final decision on whether consent to publish is required lies with the Editor.

Trial registration

SpringerOpen, as part of SpringerNature, supports initiatives to improve reporting of clinical trials. This includes prospective registering of clinical trials in suitable publicly available databases. In line with ICMJE guidelines, SpringerOpen requires registration of all clinical trials that are reported in manuscripts submitted to its journals.

The ICMJE uses the World Health Organization (WHO) definition of a clinical trial, which is "any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes". This definition includes phase I to IV trials. The ICMJE defines health-related interventions as "any intervention used to modify a biomedical or health-related outcome" and health-related outcomes as "any biomedical or health-related measures obtained in patients or participants". Authors who are unsure whether their trial needs registering should consult the ICMJE FAQs for further information.

Suitable publicly available registries are those listed on the ICMJE website as well as any of the primary registries that participate in the WHO International Clinical Trials Registry Platform, including the ISRCTN registry, which is administered and published by SpringerOpen.

The trial registration number (TRN) and date of registration should be included as the last line of the manuscript abstract.

Publication of study protocols reduces the risk of non-publication of research findings and facilitates methodological discussion, and is encouraged by a number of SpringerOpen journals. If the study protocol for a trial has been published, then it should be cited in the manuscript.

For clinical trials that have not been registered prospectively, SpringerOpen encourages retrospective registration to ensure the complete publication of all results. Further information on retrospective registration is available from the AllTrials campaign, the Public Accounts Committee and the Department of Health.

Many journals published by SpringerOpen will consider manuscripts describing retrospectively registered studies. The TRN, date of registration and the words 'retrospectively registered’ should be included as the last line of the manuscript abstract.

Registration of systematic reviews

SpringerOpen journals support the prospective registration of systematic reviews and encourages authors to register their systematic reviews in a suitable registry (such as PROSPERO). Authors who have registered their systematic review should include the registration number as the last line of the manuscript abstract.

Availability of data and materials

Submission of a manuscript to a SpringerOpen journal implies that materials described in the manuscript, including all relevant raw data, will be freely available to any scientist wishing to use them for non-commercial purposes, without breaching participant confidentiality.

For all journals, SpringerOpen strongly encourages that all datasets on which the conclusions of the paper rely should be available to readers, and where there is a community established norm for data sharing, SpringerOpen mandates data deposition (for data types with required deposition, see below).

We encourage authors to ensure that their datasets are either deposited in publicly available repositories (where available and appropriate) or presented in the main manuscript or additional supporting files, in machine-readable format (such as spreadsheets rather than PDFs) whenever possible. Please see the list of recommended repositories. For several journals, deposition of the data on which the conclusions of the manuscript rely is required. Please check the individual journal’s Submission Guidelines for more information.

Authors who need help understanding our data sharing policies, finding a suitable data repository, or organising and sharing research data can access our Author Support portal for additional guidance.

Availability of data and materials section

All authors must include an “Availability of Data and Materials” section in their manuscript detailing where the data supporting their findings can be found. Authors who do not wish to share their data must state that data will not be shared, and give the reason.

Availability of data and materials statements can take one of the following forms (or a combination of more than one if required for multiple datasets):

SpringerOpen endorses the Force 11 Data Citation Principles and requires that all publicly available datasets be fully referenced in the reference list with an accession number or unique identifier such as a digital object identifier (DOI).

List of recommended repositories

A list of recommended repositories by subject area and data type can be found on the Springer Nature Recommended Repositories list.

Community-established norm of data deposition

Mandatory deposition

Suitable repositories

DNA and RNA sequences

DNA and RNA sequencing data

Linked genotype and phenotype data

Microarray data (must be MIAME compliant)

Crystallographic data for small molecules

Publication of clinical datasets

For datasets containing clinical data, authors have an ethical and legal responsibility to respect participants’ rights to privacy and to protect their identity. Ideally, authors should gain informed consent for publication of the dataset from participants at the point of recruitment to the trial. If this is not possible, authors must demonstrate that publication of such data does not compromise anonymity or confidentiality or breach local data protection laws, for the dataset to be considered for publication. Authors must consider whether the dataset contains any direct or indirect identifiers (see here for further information) and consult their local ethics committee or another appropriate body before submission if there is any possibility that participants will not be fully anonymous. Authors must state in their manuscript on submission whether informed consent was obtained for publication of patient data. If informed consent was not obtained, authors must state the reason for this, and which body was consulted in the preparation of the dataset.

Software and code

Any previously unreported software application or custom code described in the manuscript should be available for testing by reviewers in a way that preserves their anonymity. The manuscript should include a description in the Availability of Data and Materials section of how the reviewers can access the unreported software application or custom code. This section should include a link to the most recent version of your software or code (e.g. GitHub or Sourceforge) as well as a link to the archived version referenced in the manuscript. The software or code should be archived in an appropriate repository with a DOI or other unique identifier. For software in GitHub, we recommend using Zenodo. If published, the software application/tool should be readily available to any scientist wishing to use it for non-commercial purposes, without restrictions (such as the need for a material transfer agreement). If the implementation is not made freely available, then the manuscript should focus clearly on the development of the underlying method and not discuss the tool in any detail.

Standards of reporting

SpringerOpen advocates complete and transparent reporting of biomedical and biological research. For biomedical and biological research, the checklist below must be completed before peer review, and made available to the Editors and reviewers.

We strongly recommend that authors refer to the minimum reporting guidelines for health research hosted by the EQUATOR Network when preparing their manuscript, and FAIRsharing.org for reporting checklists for biological and biomedical research, where applicable.

In addition, SpringerOpen strongly encourage the use of the following checklists and reporting guidelines: